Pentosan Injections for Osteoarthritis: Evidence, Safety and Why We No Longer Prescribe Them
Pentosan polysulfate (PPS) injections have attracted considerable interest as a potential treatment for knee osteoarthritis and bone marrow lesions.
Many patients search online for information about pentosan injections because early research has suggested the drug may improve joint pain and possibly influence the underlying disease process.
At Progressive Sports Medicine, we frequently receive enquiries about pentosan injections.
However, Dr David Samra does not currently prescribe pentosan injections.
This page explains:
- what pentosan is
- how it may work
- the current clinical evidence
- the regulatory status in Australia
- the potential safety considerations
- why we have chosen not to prescribe it at this time
Our goal is to provide balanced, evidence-based information so patients can make informed decisions.
